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Philadelphia Inquirer - October 6, 2010

Media Outlet: 

Philadelphia Inquirer



With the blessing of Temple and the support of the university's School of Pharmacy, Magid Abou-Gharbia, director of Temple's Moulder Center for Drug Discovery Research, is adding 11 researchers to his center, collaborating with doctors and scientists throughout the university and teaming with area bio-tech companies to accelerate the search for treatments for some of the most vexing health problems. "In one room, we have three-quarters of a million dollars in equipment to do screening," Abou-Gharbia said. "We are actually screening compounds against targets implicated in diseases." The center provides designer work as well, refashioning and improving chemical compounds known to be effective. "Sometimes, the good news is we have identified a preliminary chemical that can do something good," said Domenico Pratico, a professor at Temple's School of Medicine who is collaborating with the Moulder Center to find treatment for Alzheimer's disease. "The bad news is it is not very potent or effective. Magid's job is to take this molecule and make variations of it that might be more effective, more potent, variations we can test."